ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF THE PLANT ERVATAMIA CORONARIA (STAPF.)Abstract
The present study was conducted to evaluate the analgesic and anti-inflammatory potential of the flowers of Ervatamia coronaria. The analgesic activity of the extract was assessed by the acetic acid induced writhing test. Aspirin was used as a standard drug. The anti-inflammatory activity was evaluated by carrageenan induced rat hind paw edema method. The initial paw volume was measured plethysmographically immediately before subplanter injection. The relative increase in the paw volume was measured in control, standard and treated groups, 4h after carrageenan injection. The results of acetic acid writhing test in mice showed a significant decrease in number of wriths in ethanolic extracts of flowers of E. coronaria, suggesting peripheral analgesic effect. In carrageenan induced rat hind paw method; it was found that ethanolic extract of the flowers of E. coronaria, at a dose of 400 mg/kg body weight significantly reduced the oedema volume, which was comparable to standard drug diclofenac sodium. The flowers of the plant exhibited significant analgesic and anti-inflammatory activity, thereby justifying their use in traditional system of medicine.
Himanshu Joshi*, Arun B Joshi, D. Satyanarayana, M.P. Gururaja and C.S Shastry
Nitte Gulabhi Shetty Memorial Institute of Pharmaceutical Sciences, Paneer, Mangalore 575018, Karnataka, India
25 December, 2012
21 January, 2013
13 March, 2013
01 April, 2013