ANALGESIC, PHYTOCHEMICAL AND ACUTE TOXICITY EVALUATION OF THE METHANOL EXTRACT OF THE LEAVES OF PTEROCARPUS SANTALINOIDES- FAMILY FABACEAAbstract
Pterocarpus santalinoides, family- Fabaceae was claimed to have analgesic properties. The people of Ogidi in Idemili North Local Government Area of Anambra State, Nigeria used it in the management of aches and pains. This study is therefore aimed at determining this claim of the activities of Pterocarpus santalinoides using the leaves which will serve as a criterion to recommend the ethno pharmacological use of the plant. The leaves of Pterocarpus santalinoides family Fabaceae were dried, powdered and extracted by cold maceration with methanol for 48hrs, it was concentrated using rotary evaporator. The analgesic activity was investigated in rats using hot plate method at a temperature of 40oC. Phytochemical evaluation revealed the presence of tannins, flavonoids, terpenoids, steroids, alkaloids, glycosides, saponins and resins. Pterocarpus santalinoides extract (300 mg/kg) induced analgesia in rats (p< 0.05) and this effect was comparable to that of Aspirin (100 mg/kg). Acute toxicity test also revealed that the drug is safe. The claimed benefits of Pterocarpus santalinoides in traditional medical management of aches and pains could be supported by the results of this investigation.
C.F. Anowi*, B.O. Umeokoli , A.F. Onyegbule , C. Okonkwo and I. Chibeze
Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, PMB 5025 Awka
05 March, 2012
22 June, 2012
27 June, 2012
01 July 2012