ANIMAL MODELS OF CHEMICAL-INDUCED ALZHEIMER’S DISEASE: AN OVERVIEWAbstract
Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer’s disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger, aggression, and irritability. Today’s world attempts to treat various ailments have increased with medical advancements. There is still considerable research into medications capable of preventing or at least effectively altering the trajectory of AD, referred to as ‘disease-modifying medicines. Laboratory animals are helping to test new ways of treating illness. For the goal of developing therapeutics or disease-modifying agents, a vast array of experimental models were developed to simulate the human context of the illness. In animal studies, AD caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. The anticholinergic drug Scopolamine induces amnesia in rodents. This analysis examines the various animal models frequently used to research the effect of novel drugs or medicinal herbs on chemical-induced Alzheimer’s disease, such as scopolamine. This article provides an explanation of behavioral testing and the assessment of brain enzyme levels.
Rashda Khatoon, Vanita G. Kanase *, Abhaykumar Yadav, Nitesh Gupta, Shivam Varma and Sayali Shete
Department of Pharmacology, Oriental College of Pharmacy, Navi Mumbai, Maharashtra, India.
28 December 2020
12 May 2021
29 May 2021
01 January 2022