ANTI-ARTHRITIC POTENTIAL OF BIOPOLYMERIC FRACTION OF SEEDS OF TRIGONELLA FOENUM GRACEUM ALONE AND ITS COMBINATION WITH GLYCYRRHIZIN AS A BIO-ENHANCERS IN ARTHRITIC RATSAbstract
Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disorder. It is characterized by inflammation of the synovial joints and concomitant destruction of cartilage and bone. However, rheumatoid arthritis is typically a progressive illness that has potential to cause joint destruction and functional disability. In the present research, GSH content were significantly decreased in arthritic control group when compared to normal control group. Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, causes increase in GSH content, which was comparable with standard drug Dexamethasone. Change in body weight is in response to the incidence and severity of arthritis and used to assess disease onset. Weight loss is associated with increased production of pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1. Adjuvant arthritis is characterized by reduced body weight. The body weight of arthritic control rats decreased compared to the normal control group due to FCA administration. Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, recovered the body weights, significantly which was comparable with standard drug Dexamethasone.
Santosh Ghule *, Praveen Sharma, Kiran B. Kotade and Tanvirsing Rajput
Samarth College of Pharmacy, Belhe, Junnar, Pune, Maharashtra, India.
02 June 2022
06 August 2022
18 November 2022
01 February 2023