ANTI-BACTERIAL EFFICACY OF PHYTOGENIC SILVER AND GOLD NANOPARTICLES OF LANTANA CAMARA. LINN AGAINST ENTERIC PATHOGENS

Antibiotic resistance could be a natural phenomenon that occurs when an antibiotic loses its ability to control or kill the bacterial growth; in other words, the bacteria become “resistant” and still continue to multiply in the presence of therapeutic levels of an antibiotic. Nano-technology is one of the foremost active areas in modern science. Nano particles exhibit a completely new or improved particle based on the specific characteristics. Plant extracts generally have excellent potential as antimicrobial compounds against microorganisms. Thus, they can be utilized in the treatment of infectious diseases caused by resistant microbes. The current study explores the phytochemical screening of aqueous extracts of Lantana camara, which had revealed the presence of flavonoids tannins, terpenoids, saponins, steroids, and alkaloids. Formation and stability of silver and gold nanoparticles in aqueous colloidal solution are confirmed using UV-Vis spectral, FTIR, XRD, SEM and EDX analysis. The antibacterial activity of crude, ethanol, and methanol extracts and plant-mediated silver and gold nanoparticles were done. The study concludes that the crude extracts showed the maximum antibacterial activity against all the entero pathogenic strains rather than others. Following these, the plant-mediated silver and gold nanoparticles also showed the best result of antibacterial activity at 20µl of concentration which can possess good activation when the concentration is increased. The plant-mediated nanoparticles will be cost-effective, eco-friendly, and efficient drugs for the treatment in controlling the disease particularly the diarrheal outbreak.