ANTI-DIABETIC ACTIVITY OF LAGENARIA SICERARIA PULP AND SEED EXTRACT IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATSAbstract
The aim of the present study was to evaluate the possible anti-diabetic potential of Lagenaria siceraria pulp extract (LSPE) and Lagenaria siceraria seed extract (LSSE) against the pancreatic damage from alloxan-induced diabetes in rats related to diabetes mellitus. Lagenaria siceraria induced significant reduction in blood glucose and increasing of serum insulin, our data indicate that the level of glucose in the animals that were subjected with alloxan was 210 mg/dl comparing with normal 70 mg/dl, the level of blood glucose in diabetic group when subjected with Lagenaria siceraria extract decreased to 89-106.5 mg/dl. These findings suggest that LSPE and LSSE treatment exerts therapeutic protective effect in diabetes by preserving pancreatic cell integrity and significant activity extract, which supports traditional usage of the plant to prevent diabetic complications.
Somshuvra Bhattacharya* and Binay Das
Gurunanak Institute of Pharmaceutical Science and Technology 157/F Nilgunj Road, Kolkata-114, West Bengal, India
22 May, 2012
13 July, 2012
28 August, 2012
01 September, 2012