ANTI-DIABETIC AND ANTI-OBESITY EFFECT OF FUNCTIONALLY ACTIVE PROTEINS OBTAINED FROM SEVEN EDIBLE INSECTSAbstract
The bioactive peptides derived from food have increased consideration for their function in averting numerous chronic diseases, comprising, diabetes and obesity. Edible insects are the feasible composition of bioactive peptides owing to their high protein content and viable production. The present study was aimed to evaluate the antidiabetic and anti-obesity effects of seven edible insects’ protein hydrolysates after simulated gastrointestinal enzymatic digestion. Antidiabetic and anti-obesity efficiency was determined by the inhibition of digestive enzymes viz., dipeptidyl peptidase-IV, α-glucosidase, and α-lipase activity. Three active protein hydrolysate extracts (1.25, 2.5, and 5mg/dl) were selected and analyzed in terms of their IC50 values, and all tested extracts inhibited those enzyme activities in a dose-dependent manner. Based on the present study, we conclude the seven edible insects’ hydrolysate have potential enzyme inhibitory activities and thereby proved as an antidiabetic and anti-obesity activity.
P. Matheswaran, L. Raja and S. B. Gani *
PG and Research Department of Zoology, NKR Government Arts College for Women, Namakkal, Tamil Nadu, India.
24 September 2019
19 February 2020
11 March 2020
01 September 2020