ANTI-DIABETIC PROFILE OF CINNAMON POWDER EXTRACT IN EXPERIMENTAL DIABETIC ANIMALSAbstract
Objective: to investigate the anti diabetic effect of ethanolic extract of Cinnamomum zeylanicum on Alloxan induced diabetes in experimental animals (Rats). Materials and Methods: the alcohol extract of Cinnamomum zeylanicum was tested for its efficacy in Alloxan (150mg/kg) induced diabetic rats. The diabetic rats were divided into 5groups. Group I (control) received 2% gumacasia, group II (positive control) received standard drug Glibenclamide (10mg/kg+2%GA), group III, IV, V (T1 T2 T3) were treated orally with a daily dose of 50mg/kg, 100mg, 200mg, respectively for 30 days, for all diabetic rats after giving TEST, NC, PC preparations, the blood samples were collected & the blood glucose levels determined at 0, 1…, 0 hr reading is before giving the drug & the remaining three readings after giving the drugs. 24th hr reading is considered as 0hr reading for the next day. Results: administration of alcohol extract of Cinnamomum zeylanicum produced a dose dependent decrease in blood glucose levels in Alloxan induced rats. There was significant fall in blood sugar level in High dose (200mg/kg) in comparison to low dose (50mg/kg) and median dose (100mg/kg) shown by LSD test. This is comparable to the effect of Glibenclamide. Conclusion: the results of this study show that chronic oral administration of an extract of Cinnamomum zeylanicum at an appropriate dosage may be good alternative anti diabetic agent
Pusuloori Rajesh, S. Sharon Sonia. , Y. Vijayabhaskara Reddy and M. Shiva Kumar
Department of Pharmacology of Kurnool Medical College, Kurnool, A. P., India.
28 July, 2015
22 September, 2015
28 September, 2015
01 October, 2015