ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF MERREMIA TRIDENTATA ON MURINE MODELSAbstract
The present study aims to reveal the anti-inflammatory activity of the ethanolic plant extracts of Merremia tridentata against murine models. The Wistar Albino rats of mixed sex were induced inflammation via injecting histamine and formalin. The anti-inflammatory effect of Merremia tridetata was compared with the presence of positive control, Indomethacin. The Paw volume of the control group (group I and group II) have revealed the following mean and standard deviation values of 7.91±0.22 ml and 5.66±0.27 ml, respectively. Whereas the minimum and maximum dosages of plant extracts have shown the values 6.1±0.29 (200 mg/kg) and 5.49±0.18 ml. similarly, the histamine and Indomethacin control group I have revealed the following values 7.96±0.2 ml (group I) and 6.02±0.53 ml (group II). Likewise, the minimum and maximum dosage of plant extracts have revealed the maximum anti-inflammatory effect with the following values 6.30±0.60 ml (200 mg/kg) and 6.13±0.47 ml (400mg/kg). Hence, the present study has exerted the potential biological effect of M. tridetata might be useful for the development of alternative medicine for inflammation.
M. Manimegalai *, S. S. Prasad, T. S. Subha and L. Suguna
Department of Botany, Bharathi Women’s College, Chennai, Tamil Nadu, India.
03 April 2020
28 September 2020
02 April 2021
01 May 2021