ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF BRASSICA JUNCEA SEED ON CARRAGEENAN INDUCED PAW EDEMA IN RATSAbstract
Inflammation is a primary physiological defense mechanism that helps the body to protect itself from infection, toxic chemicals, or other noxious stimuli. The methanolic seeds extract of Brassica juncea was evaluated for its anti-inflammatory activity, in-vivo methods. Anti-inflammatory drugs with low toxicity and higher therapeutic values. It is a defensive mechanism of the body to remove the injurious stimuli as well as initiate the healing process for the tissue Brassica juncea has been used since ancient times, and it is popularly known as mustard. Present study aimed to evaluate the anti-inflammatory activity of methanolic extract of Brassica juncea against carrageenan-induced paw edema test at different doses (500 and 1000 mg/kg body weight) of the methanolic extract. At the dose of 1000 mg/kg body weight, the extract showed significant anti-inflammatory activity in the carrageenan-induced edema test models in rats showing 65.98% reduction in the paw volume comparable (P<0.05) to that produced by the standard drug indomethacin 81.96% at 5 hours respectively. The results of this study explicate justification of the use of this plant in the treatment of inflammatory disease conditions.
Y. S. Chouhan *, H. C. Kataria and C. S. Gosawmi
Department of Chemistry, Govt. Geetanjali Girls P.G. College, Barkattulla University, Bhopal, Madhya Pradesh, India.
10 March 2014
23 April 2014
07 June 2014
01 September 2014