ANTI-INFLAMMATORY, ANALGESIC AND ANTIMICROBIAL ACTIVITIES OF SOME SYNTHETIC FURANONES AND THEIR PYRROLONE DERIVATIVESAbstract
In the present study, 3-naphthoyl propionic acid and various appropriate reagents were used to synthesize, ten new synthetic furanone derivatives, i.e. 3-arylidene-5-(naphthalen-2-yl) furan-2(3H)-one (2-11). Selected furanones were made to react with ammonia and benzylamine to yield analogous pyrrolones (12-16) and N-benzyl pyrrolones (17-21), respectively, which were characterized on the basis of 1H NMR, Mass spectroscopic data. Synthesized compounds were tested for anti-inflammatory activity by the carrageenan-induced rat paw edema method, compounds displaying compelling anti-inflammatory activity were screened for analgesic activity by employing the acetic-acid induced writhing method, and selected compounds were tested for ulcerogenic activity. Screening of the newly synthesized compounds was also done for their antibacterial profile against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and antifungal activity against Aspergillus flavus, Aspergillus niger. One of the derivatives numbered (9) displayed strong anti-inflammatory, analgesic, and antimicrobial activities, and it could prove as a promising candidate for the development of new and safer leads.
I. Rani *, S. L. Khokra, G. Kaur and P. Sharma
MM School of Pharmacy, Maharishi Markandeshwar University, Sadopur-Ambala, Haryana India.
11 June 2020
08 December 2020
04 May 2021
01 June 2021