ANTI – INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITY OF TWO SIDDHA FORMULATIONS IN COMBINATIONAbstract
In Siddha system of medicine, the two formulations Vedikara silasathu parpam and Nerunjil kudineer in combination is given for urinary tract infection. Inhibition in the synthesis of inflammatory mediators and prostaglandins owe to the anti- inflammatory and antinociceptive properties of the drugs. In this study, the two Siddha formulations VSP and NK in combination was evaluated for anti- inflammatory activity by means of carrageenan induced rat paw edema method and antinociceptive activity with tail flick method in Wistar albino rats. In the carrageenan induced paw edema technique, rats at the dosage of 500mg/kg/p.o of VSP and NK, significant (p<0.001) inhibition of inflammatory progression was observed than the control group. In the tail flick method, VSP and NK at dosage of 500 mg dose, increased the tail withdrawal time significantly (p<0.001) when compared to the control group. This study had established the significant anti- inflammatory and antinociceptive activity of VSP and NK.
B. Akila* and K. Manickavasakam
Department of Maruthuvam, National Institute of Siddha, Chennai-47, Tamil Nadu, India
20 October, 2012
20 November, 2012
28 January, 2013
01 February, 2013