ANTI-INFLAMMATORY EFFECT OF THE MOLECULAR PECTIN COMPLEX WITH ACETYLSALICYLLIC ACID ON A MODEL OF CARRAGEENAN PAW EDEMA IN RATSAbstract
The aim of this work is a comparison of anti-inflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that of P-ASA at equimolar doses. P-ASA contributes to normalization of blood leukocyte profile. P-ASA may be recommended to using as anti-inflammatory agent with low ulcerogenic properties.
A. B. Vyshtakalyuk *, K. N. Bushmeleva, O. A. Lenina, L. F. Gumarova, S. T. Minzanova, A. A. Parfenov, G. P. Belyaev, L. G. Mironova, E. V. Chekunkov and V. V. Zobov
Laboratory of Chemical-Biological Researches, A. E. Arbuzov Institute of Organic and Physical Chemistry - Subdivision of the Federal State Budgetary Institution of Science "Kazan Scientific Center of Russian Academy of Sciences", Kazan, Russia.
28 May 2019
24 September 2019
30 November 2019
01 April 2020