ANTI-MICROBIAL AND ANTI-TUBERCULAR ACTIVITY EVALUATION OF NEWLY SYNTHESIZED ZINC COMPLEXES OF AMINOTHIOPHENE SCHIFF BASESAbstract
Tridentate Schiff bases were obtained in succession from the condensation of ethyl 2-amino-5,6-dihydro-4H-cyclopenta [b] thiophene-3-carboxylate and different aryl aldehydes in 1:1 molar ratio. Zinc chloride complexes of these new aminothiophene Schiff bases were prepared in 1:1 metal: ligand stichometry. These complexes were characterized using IR, UV-Visible, elemental analysis and molar conductivity. Schiff bases displayed monobasic tridentate coordination with central Zn (II) ion and formed tetrahedral complexes. These complexes were evaluated for their antimicrobial activity against gram-negative, multidrug-resistant Metallo- β-lactamase (MBL) and Extended Spectrum β-lactamase (ESBL) producing uropathogens and for their antitubercular activity against Mycobacterium tuberculosis (H37Rv strain) to observe improved biological activity compared to parent Schiff bases.
G. More, S. Bootwala *, S. Shenoy, J. Mascarenhas and K. Aruna
Department of Chemistry, Wilson College, Girgaon Chowpatty, Mumbai, Maharashtra, India.
28 October, 2017
15 December, 2017
25 December, 2017
01 July, 2018