ANTI-OXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF SYNTHESIZED 3(SUBSTITUTED) CHROMEN-2-ONEAbstract
This study was designed to investigate the in vitro anti-oxidant and in vitro anti-inflammatory potential of synthesized 3(Substituted) Chromen-2-one. Anti-oxidant activity has done by DPPH, NO and H2O2 free radical scavenging activity, ascorbic acid was used as a standard. Anti-inflammatory activity has done by membrane stabilization method; aceclofenac sodium was used as standard. The presence of OCH3 group in aromatic ring system of the compound prompted us to evaluate its anti-oxidant and anti-inflammatory activity. Some of the synthesized compounds which contains OCH3 group has been found to be having high anti-oxidant and anti-inflammatory activity by various in vitro models.
B. Lakshmi Narayanan*, L. A. Pradeep Rajkumar , A. Arulanandham , N. Satheesh Babu T. Gayathri and A. Raju
M. Pharm, (Ph. D)., Asst. Professor, Dept. of Pharmaceutical Chemistry, Karpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore- 41032, Tamil Nadu, India
26 September, 2011
16 November, 2011
29 January, 2012