ANTI TUBERULAR AND ANTHELMINTHIC ACTIVITIES OF AQUEOUS METHANOLIC EXTRACT OF CARALLUAMA ATTENUATAAbstract
Caralluma attenuata is a perennial small, leafless succulent plant which grows in tropical and subtropical areas. It belongs to the family Apocyanaceae. The folkal information reveals that the tribes generally chew the whole plant to treat peptic ulcer, diabetes, in weight reduction to suppress hunger and also to produce endurance. It has been reported for the presence of steroids, flavanoids, saponins, triterpenes and pregnane glycosides etc., several biological activities like anti-diabetic and anti ulcerogenic were reported. In the present study an attempt is made to evaluate Anti tubercular and Anthelminthic activities for aqueous methanolic (50:50) extract after carrying out the phytochemical investigations. Anti tubercular activity was evaluated by Micro plate Alamar blue assay method against streptomycin, ciprofloxacin and pyrazinamide as standard drugs. Anthelminthic activity was evaluated on Perithima posthuma using Piperazine citrate as standard drug. The results obtained for biological activities were shown to posses considerable Anti tubercular activity at 50 µg/ml and Anthelminthic activity at 300mg/ml.
P. Mounika, M. Vijaya Jyothi *, P. Ramalingam, Vinusha Reddy J. and K. Anusha
Department of Pharmaceutical chemistry 1, Raghavendra Institute of Pharmaceutical Education &Research, Ananthapuramu, Andhra Pradesh, India
02 June, 2016
21 July, 2016
02 August, 2016
01 November, 2016