ANTI-TUMOR ACTIVITY OF TARAXACUM OFFICINALE LAM. LEAVES AGAINST DMBA-INDUCED SKIN CANCER IN SWISS ALBINO MICEAbstract
Objective: To investigate the antitumor activity of different extracts (petroleum ether, ethanolic and aqueous extracts) of Taraxacum officinale against DMBA-induced skin cancer in mice. Methods: T. officinale leaves were successively extracted using petroleum ether (PTO), ethanol (ETO) and water (ATO). The antitumor activity was evaluated against DMBA-induced skin cancer in swiss albino mice. The morphological and biochemical parameters were observed inrelation to the skin papilloma. Results: PTO, ETO and ATO were administered at dose of 200 mg/kg body weight, respectively to DMBA-induced skin cancer in mice. All the treatment groups showed a significant (P < 0.05) improvement in all biochemical parameters by restoring to the normal level. The morphological study confirmed that the treatment groups showed a significant reduction in tumor size and the tumor number compared with group II. ETO extract was found to be highly effective against DMBA-induced skin cancer in mice as compared to PTO & ATO groups. Conclusion: The results were significant and confirmed that the T. officinale ETO extract has remarkable antitumor activity against DMBA Induced skin cancer in mice.
Madan Lal Kaushik, Manpreet Singh, Deepika Rani * and Ranjit Singh
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.
27 July 2022
27 August 2022
20 October 2022
01 April 2023