ANTI-TUSSIVE ACTIVITY OF ETHYL ACETATE AND METHANOL EXTRACTS OF ADHATODA VASICA NEESAbstract
The present study was carried out to evaluate anti-tussive activity of ethyl acetate and methanolic extract of leaves of Adhatoda vasica Nees. As cough is a natural reflex expulsive defense mechanism of the body, it is the most common symptom of respiratory disease. Ammonium hydroxide and Sulphur dioxide induced cough models in mice were used for evaluation of antitussive activity of ethyl acetate and methanolic extracts of leaves Adhatoda vasica. The ethyl acetate and methanolic extract of leaves Adhatoda vasica was orally administered at the dose levels of 500 mg/kg b.w. showed maximum inhibition of cough by 82% and 81% respectively .The standard anti-tussive drug Codiene phosphate (10mg/kg b.w.) showed maximum inhibition of cough by 84%. It was found that both extracts of Adhatoda vasica showed anti-tussive activity and obtained percentage inhibition of cough reflex is approximately comparable as standard drug.
Sweta Srivastava* and G. P. Choudhary
Department of Pharmacognosy, School of Pharmacy, DAVV, Indore, Madhya Pradesh, India
12 May, 2016
04 July, 2016
15 July, 2016
01 October 2016