ANTI ULCER ACTIVITY OF HELIOTRPIUM INDICUM LEAVES EXTRACT
AbstractThe objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl- Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCI-Ethanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity of plant extract was observed in all the models. Pylorus ligation model showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed significant ulcer inhibition in HCl- Ethanol induced ulcer and ulcer protection index in stress induced ulcer. This present study indicates that Heliotropium indicum leaves extract have potential anti ulcer activity in the three models tested.
Article Information
30
1288-1292
486
1232
English
Ijpsr
Ashoka M. Shenoy*, Shashidhar C. Shastry and Prakash Shetiya
Department of Pharmacology, Srinivas College of Pharmacy, Mangalore, Karnataka, India
21 February, 2011
25 March, 2011
April, 2011
30. http://dx.doi.org/10.13040/IJPSR.0975-8232.2(5).1288-92
01 May, 2011
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