ANTI-ULCER ACTIVITY OF POLYHERBAL FORMULATION ACIDEZ IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATS

Aim and Objective: Acid-related health problems mostly affect the quality of life and are a major factor in morbidity and mortality in patients. This study is designed to evaluate the anti-ulcer activity of Polyherbal formulation ACIDEZ against experimentally induced gastric ulcers in rats. Methodology: To determine anti-ulcer activity, ulcers were induced by aspirin plus pylorus ligation and acetic acid induced methods. The animals were treated with ACIDEZ (50 mg/kg and 100mg/kg) and the standard drug sucralfate (300mg/kg) for a particular number of days. Anti-ulcer and gastric protection activity was evaluated by ulcer index, gastric secretion, total mucosal content, and pepsin content. The results were expressed as Mean ± S.E.M., and statistical evaluation was done by one-way ANOVA followed by Tukey’s multiple comparison tests. Results and Discussions: The Polyherbal formulation ACIDEZ was found to be safe upto 2000mg/kg. ACIDEZ demonstrated a dose-dependent decrease in gastric juice volume and total acidity in both models. Both doses of the test formulation exhibited a significant decrease in ulcer index, pepsin content and restoration of mucosal content. Conclusion:-The results obtained from our study indicate that Polyherbal formulation ACIDEZ was safe and exhibited anti-ulcer activity, which might be through cytoprotective action.