ANTI-ULCER ACTIVITY OF POLYHERBAL FORMULATION ACIDEZ IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATSAbstract
Aim and Objective: Acid-related health problems mostly affect the quality of life and are a major factor in morbidity and mortality in patients. This study is designed to evaluate the anti-ulcer activity of Polyherbal formulation ACIDEZ against experimentally induced gastric ulcers in rats. Methodology: To determine anti-ulcer activity, ulcers were induced by aspirin plus pylorus ligation and acetic acid induced methods. The animals were treated with ACIDEZ (50 mg/kg and 100mg/kg) and the standard drug sucralfate (300mg/kg) for a particular number of days. Anti-ulcer and gastric protection activity was evaluated by ulcer index, gastric secretion, total mucosal content, and pepsin content. The results were expressed as Mean ± S.E.M., and statistical evaluation was done by one-way ANOVA followed by Tukey’s multiple comparison tests. Results and Discussions: The Polyherbal formulation ACIDEZ was found to be safe upto 2000mg/kg. ACIDEZ demonstrated a dose-dependent decrease in gastric juice volume and total acidity in both models. Both doses of the test formulation exhibited a significant decrease in ulcer index, pepsin content and restoration of mucosal content. Conclusion:-The results obtained from our study indicate that Polyherbal formulation ACIDEZ was safe and exhibited anti-ulcer activity, which might be through cytoprotective action.
Atul Desai *, Hemshree Desai, Rutvij Desai, Ankit Merai, Chirag Desai, Kaynat Mulla and Arindam Paul
Dhanvantari Clinic, Ayurveda Health Care and Research Centre, Vyara, Gujarat, India.
29 May 2022
09 July 2022
03 August 2022
01 February 2023