ANTI-ULCER EFFECT ON THE ETHANOL EXTRACT OF THE BARK & ROOT OF FICUS RELIGOISA LINN. IN DIFFERENT EXPERIMENTAL ULCER MODELS IN RATSAbstract
Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective model. Animals pretreated with ethanolic extract of Ficus religiosa L at the dose 200 mg/kg and 400 mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggested that the extract at 200 mg/kg and 400 mg/kg showed significant protection (P<0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that Ficus religiosa L. bark and rootextract shows significant antiulcer activity.
Sonali Thorat, Dhananjay Deshmukh*, Dushant Gaikwad and Nirmala Grampurohit
VJSM’S Vishal Institute of Pharmaceutical Education & Research Ale, Junnar, Pune- 411 412 Maharashtra, India
23 November, 2012
14 February, 2013
23 February, 2013
01 March, 2013