ANTI-ULCER PROPERTIES OF ALKALOIDS ISOLATED FROM THE FRUIT PULP OF CUCUMIS METULIFEROUS (CURCURBITACEAE)Abstract
Anti-ulcer properties of the alkaloids isolated from the fruit of Cucumis metuliferous was investigated in mice. Ethanol-induced gastric lesion was used to assess the anti-ulcer activity. In this study, there was a significant (p<0.05) decrease in haemorrhages and ulcerations of the gastric mucosa at 500 and 1000 mg/kg of the alkaloid compared with control. The activity of the extract is comparable to that of the standard control group administered ranitidine (1 mg/kg). The alkaloids of C. metuliferus showed a demonstrable potential as an anti-ulcer agent that could be used for the treatment of peptic ulcer disease.
S. Omale, N. N. Wuyep and A. Auta N. N. Wannang
Lecturer, Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria
28 May, 2011
20 August, 2011
17 September, 2011
01 October, 2011