ANTI-ULCEROGENIC EFFECTS OF ARECA CATECHU L. IN SPRAGUE DAWLEY RATSAbstract
The aim of this study was to evaluate the anti-ulcerogenic activity of aqueous extract of Areca catechu L in ethanol induced ulcer model in Sprague Dawley Rats. For possible mechanism of anti-ulcerogenic potential, determination of ulcer index was done using the Merazzi-Uberti and Turba method. Also, analytical method was used to test the 10% homogenate preparation of mucosa of the glandular stomach for protein content and glutathione level. The Sprague Dawley Rats were divided into five groups. Group I was the Normal Untreated group. Group II was the alcohol treated group. Group III was the alcohol treated group and protected group using Areca nut extract 1 g/kg.bwt. Group IV was the alcohol treated group and protected using Areca nut extract 2g/kg.bwt. Group V was the alcohol treated group and protected using the positive control Ranitidine 50 mg/kg.bwt .The paper details the rationale of using Areca nut extract to protect the animals from ulcer formation. In conclusion, aqueous extract of areca nut showed potential anti-ulcerogenic effect compared to Ranitidine, which is the standard gastric anti-secretory drug.