ANTIBACTERIAL ACTIVITY AND DNA BINDING PROPERTIES OF BIVALENT METAL COMPLEXES WITH CUMINALDEHYDE BENZOYLHYDRAZONE (CABH)Abstract
Cobalt(II), nickel(II), copper(II) and zinc(II) complexes having the general formula ML2 (where, L= cuminaldehyde benzoyl-hydrazone, CABH) have been synthesized and characterized based on mass spectra, molar conductivity, FT-IR and UV-Vis spectral data. The complexes are found to be non-electrolytes. FT-IR data suggest that the CABH acts as a uni-negative bidentate ligand. The copper complex is investigated using ESR spectroscopy at room temperature and liquid nitrogen temperature (LNT). The spin Hamiltonian, orbital reduction, and bonding parameters are calculated for the complex. The interactions of these complexes with calf thymus DNA have been investigated using absorption spectrophotometry. The zinc complex binds DNA more strongly than cobalt, nickel or copper complexes. The metal complexes are screened for their antibacterial activity against pathogenic bacterial strains. Complexes showed higher activity than the ligand. Copper complex shows more activity than any other complexes under investigation.
Y. B. Nagamani, K. H. Reddy *, K. Srinivasulu, D. Dhanalakshmi and K. Anuja
Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, India.
26 December 2019
06 April 2020
12 April 2020
01 January 2021