ANTIBACTERIAL AND CYTOTOXIC ACTIVITY OF METHANOL EXTRACT OF SPILANTHES CALVA (DC) LEAVES
AbstractMethanol extract of leaves of Spilanthes calva (DC) was examined for their antimicrobial and cytotoxic properties. To determine antibacterial activities, the extract was tested against four gram-positive and six gram-negative bacteria at three concentrations (500, 800, 1000 µg disc-1) through disc diffusion method. The extract showed moderate antibacterial actions and that was increased by increasing the concentration of the sample. The maximum antimicrobial potential was obtained against Staphylococcus aureus and no sensitivity was found for Escherichia coli. Comparatively gram-positive bacteria demonstrated more susceptibility to the extract than gram-negative bacteria. Cytotoxic property of the sample was done using Brine shrimp lethality bioassay where it did not show noticeable toxicity. So, our present study reveals that the leaves extract of S. calva possess considerable antibacterial properties along with lesser amount of cytotoxicity
Article Information
16
1707-1711
512
1027
English
Ijpsr
Md. Sekendar Ali , Md. Saiful Islam , Md. Masudur Rahman , Md. Rabiul Islam , Md. Ekramul Islam, Md. Rafikul Islam*
Lecturer, Department of Pharmacy, International Islamic University, Chawkbazar, Chittagong-4203, Bangladesh
26 March, 2011
07 May, 2011
25 June, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(7).1707-11
01 July, 2011
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