ANTIBACTERIAL, INSECTICIDAL AND IN VIVO CYTOTOXICITY ACTIVITIES OF SALIX TETRASPERMAAbstract
The present study was designed to investigate antibacterial, insecticidal and in vivo cytotoxic activities of the methanol: ethylacetate (1:9) extract of leaves, barks and roots of Salix tetrasperma. Antibacterial test were done against five Gram-positive and four Gram-negative bacteria. Bark extract was active against all tested microbial species and the highest activity was shown against Escherichia coli with a zone of inhibition 12 ± 0.02 mm. The leaves extract was active against all the Gram positive bacterial strain whereas inactive against all the Gram negative bacterial strain except Shegella flexneri while root extract showed insignificant activity. In insecticidal study, the root and leaves extract of Salix tetrasperma showed moderate activity with 26% and 20% mortality rate of Tribolium castaneum at a dose of 50mg/ml in 48 hours, respectively and bark extract had no activity. In respect of in vivo cytotoxicity, Root and bark extract showed moderate cell growth inhibition, whereas leaves extract had no activity at all.
M. Saiful Islam , Ronok Zahan , Laizuman Nahar , M. Badrul Alam , Marufa Naznin , Gopal C. Sarkar , M. A. Mosaddik and M. Ekramul Haque*
Professor, Department of Pharmacy, University of Rajshahi, Rajshahi – 6205, Bangladesh
01 April, 2011
07 May, 2011
22 July, 2011
01 August, 2011