ANTIBIOTICS SUSCEPTIBILITY IN CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) AT THE SECONDARY CARE HOSPITAL IN NORTH INDIAAbstract
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 patients; the middle ear discharge sample was collected under strict aseptic conditions and antibiotic susceptibility done as per Clinical Laboratory Standards Institute guidelines. Result: 85 ear swabs were collected, and 89 bacterial isolates were identified, of which 72.94% sample with mono-microbial growth, 16.47% with polymicrobial growth, 9.41% show no growth, and the rest 1.17% was a contaminant. Among 89 isolates, 39.33% were Gram-positive, while 60.67% were Gram-negative bacteria. The most common isolates were Pseudomonas species 40.45% followed by methicillin sensitive staphylococcus aureus (MSSA) 38.20% and others 21.35%. Pseudomonas species showed 100% susceptible to colistin, linezolid, imipenem, amikacin (97%); ciprofloxacin (92%); gentamicin (95%); Ceftriaxone (83%); meropenem (93%); Netilmicin (98%) and Sulfamethoxazole and Trimethoprim(SXT) (90%). Proteusspecies was 100% susceptible to amikacin, ciprofloxacin, Imipenem, meropenem, netilmicin; ampicillin (71%); amoxicillin–clavulanic acid (85%); ceftriaxone (85%); gentamicin (85%) and SX (85%).Among Gram-positive bacteria, MSSA was 100 % susceptible to meropenem and Imipenem, amikacin (97%); gentamicin (81%); amoxicillin-clavulanic acid (91%); linezolid (92%); Netilmicin (94%); Vancomycin (91%); Colistin (97%) and SXT (41%). Conclusion: Pseudomonas and MSSA were the principal bacterial isolate responsible for causing CSOM.
A. K. Singh, S. Alok and A. Verma *
Bioorganic & Medicinal Chemistry Research Laboratory Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, India.
10 August 2020
23 October 2020
28 October 2020
01 November 2020