ANTICANCER ACTIVITY OF METHANOLIC EXTRACTS OF SELECTED MANGROVE PLANTSAbstract
Anti cancer activity of four selected mangrove plants Bruguiera gymnorrhiza, Aegiceras corniculatum, Aegialitis rotundifolia and Lumnitzera racemosa against HepG2 cell line was studied. During the present investigation, crude methanol extracts of selected mangrove plants were prepared using soxhlet apparatus. In vitro anti cancer activity of mangrove plant extracts at various concentrations (10 to 200ug/ml) was studied against the chosen cell line using MTT assay (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). All the four extracts showed anti cancer activity. Off which methanolic extract of Bruguiera gymnorrhiza has shown lower IC50 value than Aegialitis rotundifolia, Lumnitzera racemosa, Aegiceras corniculatum respectively, indicating its greater anti cancer activity. The present study indicates that the methanolic mangrove plant extracts were effective against tumor cells and possess anticancer activity.
A. R. K. Reddy * and J. Ratna Grace
M.Sc Biotechnology, Centre for Research, Dr. V.S. Krishna Govt. Degree & P.G College (A), Maddilapallem, Visakhapatnam, Andhrapradesh - 530013, India
19 April, 2016
14 June, 2016
13 June, 2016
01 September 2016