ANTICANCER APPROACH WITH NATURAL PRODUCTAbstract
The control of cancer, the second largest cause of death in the world, may benefit from the potential that resides in alternative therapies. The primary carcinogens stem from a variety of agricultural, industrial, and dietary factors. A number of natural products have been implicated as anticancer agents. Many anticancer molecules such as vincristine, vinblastine, combretastatins, taxol, podophyllotoxin, camptothecin, etc. have been isolated from plants and many of them have been structurally modified to yield better analogues for better anticancer activity with minimum toxicity. Several successful molecules like etoposide, topotecan, irinotecan, teniposide, etc. also have emerged as drugs upon modification of these natural leads and many more are yet to come. Thus there is more need to utilise alternative concept and approaches for prevention of cancer. This review focused on natural products has been implicated in cancer prevention and promoting human health.
Department of Pharmacology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India
16 June, 2011
22 September, 2011
29 September, 2011
01 October, 2011