ANTICANCER POTENTIAL OF SOLANUM JASMINOIDESAbstract
Objective: To investigate the anticancer potential of the extracts and the alkaloidal and nonalkaloidal fractions of Solanum jasminoides Paxt using in-vitro and in-vivo models. Method: The petroleum ether, methanol, and water extracts of the whole plant were prepared by successive soxhlet method. The methanol extract was treated with solvents to separate alkaloidal and non-alkaloidal fractions. All the samples were subjected to in-vitro anticancer studies using Vero, BRL-3, HEp-2, HeLa, MDCK, and A-549 cell lines. Based on the in-vitro results, the alkaloidal fraction was selected and subjected to in-vivo anticancer activity against DLA and EAC induced ascities in mice. Results: The results reveal that the extracts and the fractions show moderate to good in-vitro anticancer activity, and the alkaloidal fraction shows superior activity. In the in-vivo study, the alkaloidal fraction shows a dose dependent effect on changes in the body weight, mortality, and clinical symptoms induced by cancer cells. Conclusion: The results of the present study indicate that the alkaloidal fraction of the plant possesses good, both in-vitro and in-vivo, anticancer potential.
O. Porwal *, M. J. Nanjan, M. J. N. Chandrasekar, R. Srinivasan and S. Gupta
Scientific Assistant Natural Product, National Institute of Pharmaceutical Education and Research (NIPER-A), Ahmedabad, Gujarat, India. C/O B V Patel (PERD Centre) Ahmedabad -380054, Gujarat, India
04 March 2014
15 April 2014
07 June 2014
01 September 2014