ANTICHOLINESTERASE ACTIVITY OF PLANT EXTRACTS OF SMILAX ZEYLANICA AND SMILAX CHINAAbstract
Alzheimer’s disease is the most common neurodegenerative disease, which initially causes oxidative stresses and leads to neuronal death. It characterized by notable memory loss, cognitive impairment, and personality disorders accompanied by diffuse structural abnormalities in the brain of the aged population. The present work focused on anticholinesterase inhibiting activity Smilax zeylanica and Smilax china against neurodegenerative disorder such as Alzheimer’s diseases on animal model respectively, as proof of preliminary anticholinesterase profile. In this paper, we studied various extracts prepared from roots of Smilax zeylanica and Smilax china for their AChE -inhibitory activity using animals. The ethanolic and various extracts from the plant roots of smilax zeylanica and smilax china were screened for their acetylcholinesterase inhibitory activity by using animals and Ellman’s method. These extracts of smilax china and smilax zeylanica exhibited inhibitory activities were observed (Cortex and Hippocampus) at a concentration of 150 mg/kg, it can be used for further study to treat the neurodegenerative disorders like Alzheimer’s disease (AD).
A. Yokeshwaran *, V. V. Venkatachalam, B. Sabarisenthil and V. K. Kalaichelvan
Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.
22 September 2019
26 March 2020
28 March 2020
01 September 2020