ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF SOLANUM MELONGENA LINN. ROOTSAbstract
In the present study, Solanum melongena Linn. (Brinjal; Solanaceae), was evaluated for its antiepileptic activity against experimental seizures. The roots ethanolic extract of Solanum melongena protected mice against tonic convulsion induced by maximal electroshock, Pentylenetetrazole and Picrotoxin. It was found that ethanolic extract up to a dose of 300 mg/kg p.o. decreased the duration of tonic extensor phase and delayed the onset of time of jerk against maximal electroshock induced seizure and pentylenetetrazole induced seizure. In Picrotoxin induced seizure, the extract at a dose of 200 mg/kg significantly increased the onset of clonic- tonic convulsion. These findings suggest that extract of the roots of Solanum melongena posses anticonvulsant effect and reduce mortality. The further studies to determine the mechanism(s) and compound(s) involved in the anticonvulsant activity.
Sunil Kumar*, Ramesh K. Singh, Arvind K. Singh and M. K. Gupta
Department of Pharmacy, Rameshwaram Institute of Technology & Management, Lucknow (U.P.), India
23 July, 2010
09 September, 2010
30 October, 2010
01 December, 2010