ANTIDEPRESSANT ACTIVITY AND PHARMACOGNOSTIC EVALUATION OF ETHANOLIC EXTRACT OF STREBLUS ASPER LOURAbstract
Streblus asper Lour is traditionally used for anti-diarrheal and anthelmintic activity. The present study aims to prove the antidepressant activity in a different extract of leaves of S. asper Lin animal models. The extracts of Sterblus asper L. significantly reduced the immobility time in the forced swimming test (FST), notable at 400 mg/kg when compared with the control group. The immobility time in the tail suspension test (TST) using mice markedly reduced after acute 14 days of treatment with Despiramine Hydrochloride (30 mg/kg). Administration of extracts of Streblus asper L. at dosages of 100, 200, and 400 mg/kg significantly reduced the immobility time. The extracts of Streblus asper L. (100mg/kg) shown that the same locomotion effect as the control group. However, 200 mg/kg and 400 mg/kg doses of Streblus asper L. significantly increase locomotion, rearing, and defecation. The result obtained from the forced swimming test (FST), tail suspension test (TST), and measurement of locomotor activity test (MLAT) indicate that the ethanolic extract of the leaves of S. asper L. possesses significant antidepressant activity.