ANTIDEPRESSANT EFFECTS OF FRUIT EXTRACT OF ELAEOCARPUS GANITRUS IN FORCE SWIM TESTAbstract
The present study was designed to evaluate antidepressant effects of fruit extract of Elaeocarpus ganitrus(75% ethanol)on albino mice. Albino mice of either sex, weighing 25-30g were divided into seven groups and each group contains six animals. The animals were housed in polypropylene cages (38×23×10cm3) with not more than six animals per cage. Group I, II and III were administered orally with distilled water, fluoxetine and imipramine respectively. Group IV, V, VI and VII were administered orally with different doses (20, 40, 60 and 80 mg/kg body weight) of Elaeocarpus ganitrus fruit extract (EGFE). Antidepressant effect of EGFE assessed by forced swim test. The (EGFE) (20 and 40mg/kg) significantly decreased the immobility time and it also increased climbing and swimming time significantly. Duration of immobility of mice increased (246.00±1.73) at high dose (80mg/kg) as compared to vehicle (228.00±4.28). It is concluded that the EGFE exhibit antidepressant effect in tested animal model at low dose but at high dose it is sedative.
Amit Dadhich, Nakuleshwar Dut Jasuja*, Subhash Chandra and Gargi Sharma
Department of Biotechnology and Allied Science, Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
22 January, 2014
24 March, 2014
06 April, 2014
01 July, 2014