ANTIDIABETIC ACTIVITY OF 1-(4-(DIMETHYLAMINO)BENZYLIDENE)-5-(2-OXO INDOLIN-3-YLIDENE) THIOCARBOHYDRAZONE IN RATSAbstract
|Objective: The present study was aimed to evaluate the antidiabetic activity of 1-(4-(Dimethylamino) benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone i.e. a novel Isatin derivative diabetic rats.
Methods: The antidiabetic activity of Isatin derivative was evaluated against alloxaninduced diabetes in rats. Diabetes in rats was induced by administration of alloxan monohydrate (120mg/kg, b.w, p.o) as a single dose. The diabetic rats were treated with single dose of test compound at a dose of 50 and 100mg/kg. Blood samples were collected at different intervals and analyzed for fasting glucose levels, total cholesterol (TC), triglycerides (TG) and High density cholesterol (HDL-C) levels using respective kits.
Results: Treatment with test compound with a single dose of 50 and 100mg/kg to diabetic rats showed a significant dose dependant (p<0.01) reduction of fasting blood glucose levels along with mild change of lipid profiles (TC, TG, HDL-C) indicating the antidiabetic activity of test compound.
Conclusion: The study results confirmed the antidiabetic activity of 1-(4-(Dimethylamino)benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone in rats.
Ch. Tejasree , G. Kiran , G. Rajyalakshmi and A. Rama Narsimha Reddy*
Department of Pharmacology, Vaageswari College of Pharmacy 1, Beside LMD Police Station, Karimnagar-505481, Andhra Pradesh, India
09 January, 2014
03 March, 2014
05 May, 2014
01 July, 2014