ANTIDIABETIC ACTIVITY OF BARK AND ROOT OF CAESALPINIA BONDUEAbstract
The different extracts of the roots of Caesalpinia Bondue (Family- Fabeaccae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and chloroform extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 3h at a dose level of 250 mg/kg of body weight. The percentage protections by aqueous chloroform and ethanol extracts were 22.28 and 23% respectively. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0,3,5,7 and 10th day. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide, standard anti-diabetic drug.
Dinanath D. Patil*, Dnyandeo K. Mhaske and Gurumeet C. Wadhawa
Post Graduate Department of Chemistry, R.B.N.B. College, Shrirampur, Maharashtra, India
13 July, 2011
17 August, 2011
28 September, 2011
01 October, 2011