ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF DAUCUS CAROTA ROOTS ON ALBINO WISTAR RATAbstract
Objective: The study’s key objective is to evaluate the Antidiabetic activity of methanolic root extract of Daucus carota in normal, streptozotocin-induced Diabetic, and alloxan-induced diabetic rats. Materials and Methods: Albino Wistar rats were administered at a dose of streptozotocin 50mg/kg /day and alloxan monohydrate 150mg/kg/day i.p. for 30 days. Experimental rats were given Daucus carota root extract in two different doses of 200mg and 400mg/kg/day orally. Results: The Preliminary phytochemical investigation of Daucus carota shown that the presence of sterols, saponins, flavonoids, and triterpenoids. In this study, Daucus carota root extract was administered for 30 days and showed antidiabetic activity in STZ diabetic rats and alloxan-induced rats. Conclusion: The methanolic extract of Daucus carota roots also has potential antidiabetic activity in STZ-Nicotinamide diabetic rats. The extract also normalized the altered diabetic parameter viz. glycosylated hemoglobin, plasma cholesterol and glutathione. The decreased level of cholesterol indicates that the plant extract also has hypolipidemic activity.
Dev Sharan Chaturvedi *, Barkha Chaturvedi and Swati Grover
Department of Pharmacology, Shanti Pharmacy College Nowgowng Chhatarpur, Madhya Pradesh, India.
10 January 2023
23 March 2023
25 April 2023
01 September 2023