ANTIDIABETIC, ANTIHYPERLIPIDEMIC, ANTIOXIDANT, HEPATOPROTECTIVE AND RENAL PROTECTIVE EFFECT OF LUFFA CYLINDRICA EXTRACT AGAINST THE STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATSAbstract
The main objective of the current study was to see whether SG peel methanolic extract had antidiabetic and hepatoprotective results in streptozotocin-induced diabetic rats. Streptozotocin was administered intraperitoneally to rats to trigger diabetes. When rats had an elevated blood sugar level three days after acquiring streptozotocin, it was determined that they were diabetic. Diabetic rats were given pre-determined doses of a methanolic extract of SG. Our experimental study took 28 days to complete. Rats were fasted overnight for an oral glucose tolerance test, and antioxidant parameters were measured. Rats were euthanized after 28 days to perform histopathological tests. One of the three doses of methanolic extract of SG peels (50, 100 and 200 mg/kg) showed nearly identical findings to Glibenclamide (2.5 mg/kg). After administering sponge gourd peel extract doses, blood glucose levels were found to be depleted. The positive impact on HOMA-IR and HOMA- β, plasma insulin levels, glycated haemoglobin, and several other variables. Furthermore, antioxidant parameters, including GLUT2 and SGLT1, significantly improved in diabetic rats. Finally, in Streptozotocin-induced rats, methanolic sponge gourd concentrate had a major effect. The 200mg/kg dose, in specific, had incredible effects. Elevated concentrations of GLUT2 and SGLT1 in diabetic rats treated with SG extract relieved the pressure. Based on the result, we can conclude that SG has a potential antidiabetic effect against STZ-induced diabetes.
Vastvikta Sahai and Vikas Kumar *
Department of Pharmaceutical Sciences, Shaloam Institute of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, Uttar Pradesh, India.
03 June 2021
23 January 2023
07 February 2023
01 April 2023