ANTIDIABETIC EFFECT OF ETHANOLIC LEAVES EXTRACTS OF AZIMA TETRACANTHA LAM. IN STREPTOZOTOCIN INDUCED DIABETIC RATSAbstract
Objective: The goal of the present examination was to investigate anti-diabetic activity of Azima tetracantha Lam. leaves in streptozotocin-induced diabetic rats. Materials and Method: At a regular interval of an experimental protocol, blood glucose, insulin, glycogen, HDL, LDL, VLDL, FFA, PL, and TC and organs to bodyweight proportion were assessed in streptozotocin-induced diabetic rats. Histology of the pancreas and liver was also studied. The statistical analysis of streptozotocin-induced diabetic rats was observed in accordance to 4, 15, 30, 45, 60 days. Results: A significant decrease in blood glucose and a significant increase in insulin and glycogen were observed in diabetic rats treated with A. tetracantha Lam. treatment resulted in a significant reduction of LDL, VLDL, FFA, TC while increased HDL content is observed. Histology of diabetic rats treated with A. tetracantha Lam. showed the pancreatic β-cells regeneration. Conclusion: These findings suggest that A. tetracantha Lam. has potent anti-diabetic activity in streptozotocin-induced diabetic rats.
S. Josephinol * and T. N. Begum
Department of Biochemistry, Holy Cross College, Tiruchirappalli, Tamil Nadu, India.
01 December 2019
16 August 2020
20 November 2020
01 December 2020