ANTIDIABETIC EFFECT OF THE SAPONIN-RICH FRACTION OF THE EXTRACT OF TAMARINDUS INDICA L. ON EXPERIMENTAL HYPERGLYCAEMIAAbstract
It is estimated that more than 170 million people are suffering from diabetes globally and this number is expected to double by 2030, and the greatest increase in prevalence is, however, expected to occur in Asia and Africa. Diabetes is the most common endocrine disease and its prevalence is reaching epidemic proportion worldwide. Tamarindus indica is a slow growing tree that is resistant to strong winds and perennial. The stem-bark extract of the plant is used locally for the management of diabetes. The saponin-rich portion of the stem-bark extract of Tamarindus indica L. was investigated for its hypoglycaemic action on experimentally induced hyperglycaemic Wistar rats. The oral LD50 of the extract was found to be 1,265 mg/kg. The extract lowered the Blood Glucose Level (BGL) in the three doses used (100, 200 and 400 mg/kg) and was significant at 400 mg/kg dose after the 8th and 16th hours. The 200 mg/kg dose significantly lowered the BGL at 24 hours p < 0.02. The saponin-rich portion of Tamarindus indica Linn significantly lowered elevated BGL in the experimental animal models.
M. Yerima *
Department of Pharmacology and Toxicology Usmanu Danfodiyo University, Sokoto Nigeria
18 June, 2014
28 August, 2014
17 October, 2014
01 February, 2015