ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF LEAVES OF NYCTANTHES ARBORTRISTIS IN ADRENALINE AND ALLOXAN-INDUCED DIABETIC RATSAbstract
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis in various rat models such as normoglycemic rats and glucose-loaded rats, adrenaline-induced hyperglycemic rat models as well as alloxan-induced diabetic rats. The extract exerted a significant (P<0.05) hypoglycemic effect at a dose of 200mg/kg on normoglycemic rats for 5 hours. The extract improved glucose tolerance significantly (P<0.05) in comparison to the control (2 gm/kg p.o. glucose) group. The extract significantly (P<0.05) decreased blood glucose concentration in adrenaline (0.8 mg/kg, i.p) treated rats. The extract also significantly (P<0.05) lowered blood glucose levels in alloxan-induced rats. The antidiabetic property of leave extract was comparable to Glibenclamide (standard drug) 0.5 mg/kg p.o. dose. Therefore, this study, “Antidiabetic Potential of Hydroalcoholic Extract of Leaves of Nyctanthes arbortristis in adrenaline and alloxan-induced diabetes rats” confirms significant antidiabetic nature of leaves of Nyctanthes arbortristis.
Mona Motallebi *, Bipin Bihari Panda, Surya Narayan Das and Soumya Kanta Mishra
Department of Pharmacology, Gayatri College of Pharmacy, Sambalpur, Odisha, India.
16 February 2022
31 March 2022
24 April 2022
01 October 2022