ANTIDIARRHEAL EFFECT OF STEM BARK OF CEIBA PENTANDRA GAERTN (BOMBA-CACEAE) IN RATSAbstract
This work aimed to evaluate the antidiarrheal effect of aqueous extract of steam barks of C. pentandra. Diarrhoea was induced by intragastric administration of castor oil. Intestinal transit was evaluated by using the charcoal method. The effect of the aqueous extract on muscarinics and α-adrenergic receptors was evaluated in atropine and yohimbine presence by using charcoal method. The results obtained show that the aqueous extract (400 and 800 mg/kg) inhibits the appearance of the signs of diarrhoea and increase the onset of gastric evacuation compared to the group control. In addition, yohimbine partially raises antidiarrheal effect observed with aqueous extract at dose of 800 mg/kg, whereas atropine potentiates it. These results are in favor of an antidiarrheal effect.
R. D. G. Elion Itou *, A. W. Etou Ossibi, C. J. Morabandza, F. G. Nsondé Ntandou and A. A. Abena
Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien, Ngouabi, Brazzaville-Congo.
30 July, 2017
11 February, 2018
24 April, 2018
01 May, 2018