ANTIDIURETIC ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF PROP ROOTS OF PANDANUS FASCICULARIS LAM.Abstract
The extracts of the prop roots of Pandanus fascicularis Lam (Family: Pandanaceae) is claimed as an antidiuretic by some traditional practitioners. However, the validity of this claim has not been scientifically proven or refuted. The aim of this study was to evaluate the antidiuretic potential of ethanol and aqueous extracts of prop roots of P. fascicularis in rats following oral administration. Ethanol and aqueous extracts were prepared from P. facicularis by percolation and cold maturation, respectively. Furosemide was used as a diuretic agent to induce diuresis. Vasopressin (ADH) was used as a standard. The results demonstrated both the ethanol and aqueous extracts of P. facicularis and ADH significantly impaired the total urine output. However, antidiuretic potential of ethanolic extract was similar to that of ADH. The extracts caused a significant decrease in natriuresis and kaliuresis. From this study, we can conclude that ethanol extract of prop roots of Pandanus fascicularis has beneficial effects on anti diuretic activity. It has the potential to impart therapeutic effect in diuretic.
Jothimani Rajeswari*, Karthikeyan Kesavan and Balasundaram Jeyakar
Assistant Professor, Srinivas College of Pharmacy, Srinivas Group of College, Mangalore – 574 143, Karnataka, India
30 November, 2011
21 January, 2012
29 March, 2012
01 April, 2012