ANTIDYSLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF MEDICINAL PLANTS IN RAT MODEL OF HYPERLIPIDEMIAAbstract
The antidyslipidemic and antioxidant activities of Allium sativum (Garlic) and Aloe vera (Ghee- kuwar) extracts have been studied in two models of hyperlipidemia, triton and cholesterol rich high fat diet induced hyperlipidemia. A. sativum, A. vera and Gemfibrogil were macerated with 0.2% aqueous gum acacia and the suspension was fed orally to rats of group III, IV and V at a dose of 400mg, 1g/Kg, and 50 mg/Kg (b.w.p.o.) respectively with triton. Serum lipids were found to be lowered by Allium sativum and Aloe-vera in triton induced hyperlipidemia. On the other hand chronic feeding of these extracts to animals in cholesterol rich high fat diet induced hyperlipidemia for 30 days caused lowering in lipid and protein levels of β lipoproteins followed by an increase in α lipoproteins. The results of present study demonstrate that hypolipidemic activity of these extracts mediate through inhibition of hepatic lipid synthesis, increased faecal bile acid excretion and induced plasma LCAT activity in rats. Furthermore these extracts (100 and 200 µg/ml) inhibited the in vitro generation of superoxide anions and hydroxyl radicals in both enzymatic and non enzymatic systems.
J. Neerja, P. Verma, V. Kumar *, F. Mahdi, A. Ali Mahdi, A. K. Khanna, J. K. Saxena and R. K. Singh
Department of Biochemistry, King George’s Medical University, Lucknow, Uttar Pradesh, India
02 June, 2016
21 July, 2016
02 August, 2016
01 November, 2016