ANTIEPILEPTIC ACTIVITY OF THE WHOLE PLANT EXTRACTOF MELISSA OFFICINALIS IN SWISS ALBINO MICEAbstract
Epilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupt the nervous system and can cause mental and physical dysfunction. Based on the ethnopharmacological information of the plant, the methanol and aqueous extract of the whole plant of MELISSA OFFICINALIS was evaluated for its antiepileptic activity in Swiss Albino Mice .Antiepileptic activity was assessed by using MES and PTZ induced models (250 and 500 mg/kg). Body weight doses were used for the present study. In the MES model the methanol and aqueous extracts showed a dose dependent reduction in the duration of hind limb extensor phase. In pentylenetetrazole induced model methanol and aqueous extracts at dose level of 500mg/kg body weight showed significant reduction in the tonic convulsions induced by PTZ when compared with control group. The results suggest a possible anticonvulsant effect of the methanol and aqueous extracts of Melissa officinalis inSwiss Albino Mice.
Jalal Uddin Bhat*, Qudsia Nizami , Mohammad Aslam , Asia Asiaf , Shiekh Tanveer Ahmad and Shabir Ahmad Parray
Department of IlmulAdvia, Faculty of Medicine (U), Jamia Hamdard, New Delhi - 110062, India
18 November, 2011
23 February, 2012
26 February, 2012