ANTIFERTILITY STUDIES ON ETHANOLIC EXTRACT OF ABRUS PRECATORIUS L ON SWISS MALE ALBINO MICEAbstract
Fertility control is an issue of global and national health concern, many study have been done for the male contraception. The use of medicinal plants in different sorts of disease including fertility problem is widespread throughout the world. Though considerable progress has been made the development of highly effective, acceptable and reversible methods of contraception among females, progress possibilities on males are still slow and limited. With recent progress towards a better understanding of male reproductive physiology there is needed to develop new contraceptive modalities for male. Abrus precatorius is one of the folk medicinal plants widely used as an antifertility agent in varius places of south Asian countries including Chittagong region of Bangladesh. The aim of the present study was to investigate the antifertility activity of abrus precarious seed extract intraperitonially administered in adult swiss male albino mice. The intraperitonial administration of 40, 80 and 80 mg/kg body weight of ethanolic seed extract of Abrus precatorius shown a highly antifertility activity which done for two months. The lower concentrations (40 mg/kg body weight) of ethanolic seed extract of Abrus precatorius gave temporarily antifertility activity. But the higher dose (80 mg/kg body weight) gave relatively more permanent antifertility activity on swiss albino mice compare with the control.
Sayeed Mohammed Abu*, Hossain A. B. M. Manirul , Mondol Abdul Majid and Islam M. Anwarul
Pharmaceutical Microbiology and Pharmacology Laboratory, Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203, Bangladesh
25 August, 2011
19 October, 2011
19 December, 2011