ANTIFUNGAL, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF AILANTHUS EXCELSA BARKAbstract
Various extracts of Ailanthus excelsa bark evaluated for antifungal at a dose 1 mg/ml, anti-inflammatory and analgesic activity at a dose 200 mg/kg and 50 mg/kg of body weight. The experimental methods were used cup plate method for antifungal and formalin induced rat hind paw oedema measured by plethysmograph (mercury displacement method) for anti-inflammatory and Tail flick method for analgesic activity. Flucanazole (1 mg/ml), diclofenac sodium (200 mg/kg, orally) and Novelgin (50 mg/kg, orally) clinically used drugs were used as standards. The ethyl acetate extract showed good antifungal activity against fungal strains A. terrus, A. niger and A. flavus at 1 mg/ml and the remaining extracts showed moderate activity compared to standard flucanzole. Extracts of Ailanthus excelsa bark showed significant anti-inflammatory and analgesic activity in the above study.
Sharanabasappa B. Patil, Upender Reddy C. H. and N. M. Goudgaon*
Department of Studies and Research in Chemistry Gulbarga University, Gulbarga (Karnataka), India
22 July, 2010
08 October, 2010
06 November, 2010
01 December, 2010