ANTIFUNGAL GLYCEROGELATIN: ATTEMPT AT FORMULATION AND EVALUATION OF A POTENTIAL TRANSUNGUAL DRUG DELIVERY SYSTEMAbstract
Onychomycosis representing about 30% of mycotic cutaneous infections is the fungal infection that affects the nails. Although not life-threatening, it adversely affects the psychology of the patient whose nails become yellow, discolored, brittle, and unsightly. It may also pose serious problems in immunocompromised individuals. The current market of products for the treatment of onychomycosis includes topical antifungal gels, creams, medicated nail lacquers, and oral antifungals in the form of tablets. Other techniques like nail etching, use of microneedles & mesoscissioning are being studied. The authors propose the formulation and evaluation of glycerogelatin for an effective transungual delivery. Glycerogelatin are semisolid dosage forms comprising of glycerine, gelatin, water and drug which upon heating to temperatures slightly above body temperature melt and can be applied over the affected area. These upon cooling harden, cover the area and release the drug. The authors propose the use of HPMC for an effective glycerogetin formulation. This research article is an attempt to bring into the limelight the potential of glycerogelatins for transungual drug delivery.
R. Joshi, P. Harbola * and S. Pandey
Devsthali Vidyapeeth, College of Pharmacy, Lalpur, Rudrapur, Uttarakhand, India.
24 March 2014
27 May 2014
09 July 2014
01 October 2014