ANTIHYPERCHOLESTROLEMIC POTENTIAL OF OMEGA-3-FATTY ACID CONCENTRATE IN ALLOXAN INDUCED DIABETIC RODENTAbstract
Exhaustive study of scientific literature provides the initial evidence that omega-3-fatty acids the principal component of fish oil is responsible for exerting important biological effects when administered to population at risk of coronary heart diseases and diabetes mellitus. The main reason behind the study was to evaluate the anti-atherogenic properties of marine lipids in alloxan induced diabetic mice. Furthermore the current analysis endeavours to scrutinize the Hypoglycemic effects of the natural omega-3-fatty acids. Mice were made diabetic by a single intraperitoneal (I.P.) injection of alloxan monohydrate 150 mg/kg. Treatment with appropriate dose of omega-3-fatty acid concentrate started 7days after alloxan injection. At the end of the selected period of study the blood glucose level, and lipid profile was evaluated and the data obtained was compared with normal control and positive control. All the data were subjected to due statistical evaluation. The omega-3-fatty acid treatment led to a significant dose dependent decline in the blood glucose content (P<0.05), along with crucial reduction in the lipid profile in alloxan induced diabetic mice. Also an improvement was observed in clotting time in the mice fed on the bioactive extract compared to the control mice.
Preliminary studies suggest that omega-3-fatty acid concentrate demonstrates potential hypoglycaemic and hypolipidemic efficacy in alloxan induced diabetic rodent model.
Debashree Das , Anand Chaurasia , Prashant Sahu , Vikash K Mishra and Sushil K Kashaw *
Department of Pharmacology, Dr. Hari Singh Gour, Sagar, M. P,, India
19 October, 2014
22 January, 2015
26 July, 2015
01 August, 2015